Figure 6.

Administration of miR-126+ ELVs reduces LV fibrosis and hypertrophy 28 days after treatment. (A) Representative images of Picrosirius red-stained myocardial sections and (B) WGA + hypertrophic myocardium 28 days after vesicle treatment. (C) Quantification of fibrotic area in LV (pink) as a percentage of total LV area. (D) Quantification of average myocyte cross-sectional area and myocyte diameter as measured from WGA+ images. Low = 5 μg/kg and high = 10.0 μg/kg of ELV in PBS. Mean ± SEM. Significance was tested with one-way ANOVA with Tukey posthoc. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001. Scale bar = 1.0 mm (A) and 100 μm (B).