Table 3. Multivariate and Univariate Associations of Physicochemical Characteristics with Organ Biodistribution Presented as Distribution Coefficient (Parameter #3) Based on the Concentration Data in the Unit of %ID^a.

	Organs
	Heart	Liver	Spleen	Kidney	Lung	P-value
Nanoparticle Type	0.434	0.270	0.025*	0.625	0.416	0.037*
Core Materials	0.064	0.005**	<0.001***	<0.001***	0.029*	<0.001***
Targeting Strategy	0.859	0.984	0.969	0.229	0.970	0.275
Cancer Type	<0.001***	0.002**	<0.001***	0.001**	<0.001***	<0.001***
Tumor Model	0.952	0.936	0.568	0.926	0.620	0.023*
Shape	0.088	<0.001***	<0.001***	0.079	0.005**	<0.001***
Size	0.093	0.023*	0.014	0.118	0.021*	<0.001***
Surface Charge	0.254	0.338	0.295	0.109	0.301	0.148

^aThe result of this table is presented as distribution coefficient (Parameter #3) based on the concentration data in the unit of %ID. The results based on other methods using different units are presented in Tables S15–S19 in Supporting Information. ***P < 0.001, **P < 0.01, and *P < 0.05. Size: log-transformed hydrodynamic size.