Table 4. Differences of the Current Study Compared to Existing Relevant Studiesa.
| Wilhelm et al. (2016) | Price et al. (2020) | Cheng et al. (2020) | Fan et al. (2021) | Current study by Chen et al. | |
|---|---|---|---|---|---|
| Scope of the data | Tumor only | Tumor only | Tumor only | Tumor and major organs | Tumor, blood, and major organs |
| Years of the data | 2005–2015 | 2005–2015 | 2005–2018 | 2005–2018 | 2005–021 |
| Number of publications | 117 | 117 (Based on Wilhelm et al. 2016) | 200 | 200 (Based on Cheng et al. 2020) | 297 |
| Number of data sets | 232 for tumors | 256 for tumors | 376 for tumors | 376 for tumors and 1381 for major organs (heart: 227, liver: 327, lung: 292, spleen: 252, kidney; 283) | 534 for tumors and 1972 for major organs (heart: 340, liver: 456; lung: 367, spleen: 413, kidney: 396) |
| Characteristics of data sets | Single time point and multiple time points | Single time point or multiple time points | At least 3 time points for each data set | At least 3 time points for each data set | At least 3 time points for each data set |
| Number of data points | NA | NA | 1722 for tumors | 1732 for tumors and 6039 for major organs | 2345 for tumors and 8461 for major organs |
| Unit of data | %ID | %ID | %ID | %ID and %ID/g | %ID and %ID/g |
| PK parameters | DE for tumors only | four different parameters for tumors only | DE and the PBPK method | DE for tumors only | DE, Cmax, and DC for both tumors and major organs |
| Availability of data | Yes | No | Yes | Yes | Yes |
a
Note: Please refer to the Methods section regarding definitions of pharmacokinetic (PK) Parameter #1 – #3. DE: delivery efficiency; DC: distribution coefficient; NA: not available.