| Delivery efficiency (DE) |
Delivery efficiency = AUC/t where AUC is the area under the curve of the concentration
in the target tissue, while t is the last measured
time point in the data set. AUC is calculated based on a noncompartmental
linear trapezoidal model. |
Delivery efficiency is a
classical pharmacokinetic parameter to assess the average drug amount
or concentration in a particular tissue during the measured period. |
|
Cmax
|
The
maximum observed concentration
in the target tissue which is determined by visual inspection. |
Cmax is a standard measurement in pharmacokinetics to evaluate the maximum
concentration that a drug can achieve in the plasma or tissue. |
| Distribution
Coefficient |
Distribution
coefficient
tissue/blood = AUCtissue/AUCblood |
Distribution coefficient
represents the extent of distribution of a drug or a NP to a tissue
relative to the blood. It is a composite parameter that considers
the ratio in the amount or concentration of the drug or NP between
tissue and blood. When the AUC is calculated based on the data in
the unit of %ID, the distribution coefficient assesses the ratio of
the total drug amount between the target tissue and the blood, whereas
when the AUC is calculated based on the data in the unit of %ID/g,
distribution coefficient can assess the ratio of the concentration
between the target tissue and the blood. |
