Table 2.
Comparison of the interleukin levels of the subjects.
| Interleukins | BMI < 25 | p | BMI ≥ 25 | p | PCOS (n = 44) |
Control (n = 45) |
p ** | p *** | ||
|---|---|---|---|---|---|---|---|---|---|---|
| PCOS (n = 19) |
Controls (n = 22) |
PCOS (n = 25) |
Controls (n = 23) |
|||||||
| IL-1a | 1.3 (0.5–6.9) |
0 (0–3.2) |
0.006 | 2.56 (0.0–5.92) |
0.51 (0.0–5.92) |
0.358 | 1.3 (0.5–5.9) |
0 (0–2.5) |
0.014 | 0.723 |
| IL-1b | 11.7 (5.8–21.7) |
5.2 (0.7–16.9) |
0.124 | 13.27 (3.62–21.54) |
5.86 (1.74–17.41) |
0.230 | 13.2 (5.2–21.7) |
5.8 (1.7–16.9) |
0.052 | 0.776 |
| IL-1 RA | 1.0 (0.9–1.9) |
0.5 (0.3–0.8) |
0.001 | 1.95 (1.34–2.75) |
0.96 (0.69–1.12) |
<0.001 | 1.5 (0.9–2.2) |
0.8 (0.4–1.0) |
<0.001 | 0.004 |
| IL-2 | 0.28 (0–1.5) |
0 (0–0.6) |
0.004 | 0.43 (0.0–0.85) |
0.0 (0.0–0.14) |
0.012 | 0.43 (0–1.14) |
0 (0–0.11) |
<0.001 | 0.711 |
| IL-3 | 0.7 (0–0.2) |
0.0 (0.0–0.0) |
0.030 | 0.09 (0.0–0.29) |
0.05 (0.0–0.22) |
0.484 | 0.05 (0–0.6) |
0 (0–0.09) |
0.053 | 0.814 |
| IL-4 | 0.5 (0–0.6) |
0.0 (0.0–0.0) |
0.008 | 0.05 (0.0–0.54) |
0.0 (0.0–0.0) |
0.094 | 0.05 (0–0.6) |
0 (0.0–0.0) |
0.002 | 0.719 |
| IL-5 | 1.99 (1.24–3.35) |
1.29 (0.84–3.1) |
0.184 | 1.94 (1.39–3.99) |
1.59 (0.94–4.05) |
0.448 | 1.9 (1.3–3.6) |
1.4 (0.9–3.5) |
0.144 | 0.937 |
| IL-6 | 0.48 (0.24–1.12) |
0.0 (0.0–0.24) |
0.004 | 1.2 (0.58–2.17) |
0.32 (0.0–0.64) |
0.002 | 0.7 (0.4–1.2) |
0.07 (0–0.48) |
<0.001 | 0.009 |
| IL-7 | 0.75 (0.08–1.05) |
0.08 (0.0–0.75) |
0.050 | 0.33 (0.07–0.81) |
0.27 (0.21–1.19) |
0.644 | 0.4 (0.08–0.99) |
0.2 (0–0.87) |
0.268 | 0.345 |
| IL-8 | 1.56 (1.12–2.63) |
0.98 (0.66–1.56) |
0.034 | 1.43 (0.95–1.83) |
1.77 (1.08–2.23) |
0.116 | 1.5 (1.0–2.1) |
1.5 (0.8–1.97) |
0.534 | 0.146 |
| IL-9 | 6.71 (0.0–12.01) |
0.0 (0.0–3.99) |
0.048 | 5.26 (0.0–11.35) |
0.0 (0.0–2.56) |
0.060 | 5.7 (0–11.4) |
0 (0–3.9) |
0.007 | 0.800 |
| IL-10 | 0.0 (0.0–0.0) |
0.0 (0.0–0.0) |
0.555 | 0.0 (0.0–0.0) |
0.0 (0.0–0.0) |
0.669 | 0.0 (0.0–0.0) |
0.0 (0.0–0.0) |
0.967 | 0.963 |
| IL-12 | 22.53 (13.62–31.02) |
14.84 (7.27–19.62) |
0.012 | 21.95 (17.25–25.4) |
18.44 (9.87–27.09) |
0.176 | 21.9 (16–28.7) |
16 (9.8–20.7) |
0.005 | 0.883 |
| IL-13 | 75.93 (54.9–194.96) |
19.64 (1.22–54.9) |
<0.001 | 58.98 (31.58–128.68) |
46.26 (7.6–106.89) |
0.373 | 74.1 (43.9–143.5) |
36.7 (3–81.2) |
0.001 | 0.117 |
| IL-15 | 7.8 (4.98–8.61) |
4.8 (3.23–6.32) |
0.006 | 7.64 (6.49–9.96) |
7.31 (5.32–8.12) |
0.235 | 7.6 (5.6–9.5) |
6.3 (4.2–7.6) |
0.004 | 0.509 |
| IL-17A | 5.33 (1.57–8.82) |
0.57 (0.29–4.43) |
0.002 | 5.62 (1.98–8.82) |
1.57 (0.29–5.03) |
0.033 | 5.6 (1.5–8.8) |
0.5 (0.2–4.4) |
<0.001 | 0.882 |
| IL-17E/IL-25 | 310.25 (172.63–529.23) |
154.83 (52.69–205.93) |
0.007 | 352.69 (221.73–676.94) |
172.63 (117.52–366.08) |
0.013 | 352.6 (205.9–643.9) |
172.6 (52.6–325) |
<0.001 | 0.547 |
| IL-17F | 3.43 (1.13–7.21) |
0.73 (0.0–3.65) |
0.066 | 3.0 (1.33–7.21) |
1.13 (0.35–4.54) |
0.083 | 3.2 (1.1–7.2) |
0.7 (0–3.6) |
0.011 | 0.856 |
| IL-18 | 14.93 (9.82–20.5) |
8.84 (3.51–13.92) |
0.025 | 16.29 (10.37–24.37) |
10.18 (5.78–17.41) |
0.049 | 14.9 (10.1–22.9) |
9.7 (4.5–16.4) |
0.003 | 0.570 |
| IL-22 | 0.0 (0.0–121.66) |
0.0 (0.0–0.0) |
0.060 | 0.0 (0.0–26.1) |
0.0 (0.0–0.0) |
0.097 | 0.0 (0.0–29.1) |
0.0 (0.0–0.0) |
0.012 | 0.458 |
| IL-27 | 1478.66 (1190.23–1763.21) |
1320.66 (1070.85–1529.68) |
0.205 | 1073.96 (772.69–1476.52) |
1303.77 (1022.43–1803.25) |
0.124 | 1266 (967.7–1703.3) |
1303.7 (1058–1652.4) |
0.768 | 0.051 |
IL—interleukin, IL-1a—interleukin alpha, IL-1b—interleukin beta, IL-1 RA—interleukin-1 receptor antagonist. Note: The interleukin levels are presented in picograms per milliliter (pg/mL); **—comparing PCOS versus control without division by BMI; ***—comparing women with PCOS with BMI < 25 kg/m² and BMI ≥ 25 kg/m².