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Lung CFU/gram of the isogenic pair of E. cloacae (top panel, wild type; bottom panel, stably-derepressed cephalosporinase-producing mutant) in rats treated with either amikacin (AMK), ceftazidime (CAZ), cefepime (FEP), or imipenem (IMP) or with each β-lactam in combination with amikacin. Each mark represents a single animal. The horizontal bar indicates the median for each group.
