TABLE 2.
Pharmacokinetics for antibiotics given intraperitoneally to noninfected rats with uranyl nitrate-induced renal impairment
| Antimicrobial agent | No. of animals | Dose (mg/kg) | Median (range) antibiotic level in plasma (μg/ml)
|
Half-life (h) | Area under curve (μg × h/ml) | |
|---|---|---|---|---|---|---|
| Peak (30 min after dosing) | Trough (8 h after dosing) | |||||
| Amikacin | 6 | 25 | 80 (60–115) | 15 (10–30) | 2.2 (1.9–2.6) | 288 (224–408) |
| Ceftazidime | 4 | 60 | 197 (139–214) | 15 (5–24) | 1.9 (1.4–2.9) | 346 (266–382) |
| Cefepime | 6 | 60 | 160 (125–220) | 12 (6–28) | 2.0 (1.4–2.8) | 422 (188–615) |
| Imipenem | 5 | 30 | 83 (66–104) | <0.5 (<0.5–1) | 1.0 (0.7–1.3) | 112 (95–145) |