TABLE 3.
Creatinine and antibiotic levels in plasma observed at sacrifice
| Antimicrobial agent(s) | No. of animals | Creatinine level in plasma (μmol/liter) | Median (range) of antibiotic plasma concn (μg/ml)
|
|
|---|---|---|---|---|
| β-Lactama | Amikacinb | |||
| None | 18 | 217 (83–469) | — | — |
| Amikacin | 14 | 169 (72–353) | — | 1 (<1–10) |
| Ceftazidime | 11 | 157 (80–346) | 26 (<5–57) | — |
| Ceftazidime + amikacin | 12 | 215 (89–425) | 31 (13–57) | 1 (<1–13) |
| Cefepime | 18 | 162 (72–288) | 24 (12–48) | — |
| Cefepime + amikacin | 19 | 234 (42–559) | 27 (10–39) | 4 (<1–24) |
| Imipenem | 18 | 194 (60–446) | 1 (<1–15) | — |
| Imipenem + amikacin | 19 | 219 (102–436) | 1 (<1–12) | 3 (<1–17) |
a
Time from the last β-lactam administration to sacrifice was 4 to 6 h.
b
Time from the last amikacin administration to sacrifice was 13 to 14 h.