Figure 2.

Role of Cx-GJCs in regulating cancer cell aggressiveness. (A) illustrates the relationship between the flow of cyclic adenosine monophosphate (cAMP) via connexin 26 (Cx26) and connexin 43 (Cx43) gap junction channels (GJCs) and its impact on cell division. (B). shows that the formation of Cx43 GJCs in lung cancer cells has an inhibitory effect on the Cancer Stem Cell (CSC) phenotype. (C) However, in glioblastoma, Cx43 GJCs are involved in the increase in glioma cells’ invasiveness capacity by facilitating the exchange of microRNAs (miRNAs) between glioma cells and astrocytes. Additionally, Cx46 GJC seems to enhance CSC phenotype, however, the mechanism remains unknown.