Table 8.

The DNA-protective activity of different concentrations of YY and CCP EO against DNA damage induced by CCl₄ in the livers of albino Wistar rats.

Groups	Comet Types a					Total Comet Score (TCS)	%R b
	T0	T1	T2	T3	T4
I	72.5 ± 0.37 c	27.5 ± 0.51	NO d	NO	NO	27.5 ± 0.41 †	NA e
II	NO	61.5 ± 0.32	26.2 ± 0.81	8.5 ± 0.12	3.8 ± 0.72	154.6 ± 0.53 *	NA
III	54.2 ± 0.82	21.5 ± 0.81	19.5 ± 0.23	4.8 ± 0.56	NO	74.9 ± 0.55 *†	62.7
IV	55.3 ± 0.61	31.6 ± 0.23	11.2 ± 0.32	1.9 ± 0.51	NO	59.7 ± 0.34 *†	74.7
V	67.8 ± 0.90	23.9 ± 0.41	8.3 ± 0.71	NO	NO	40.5 ± 0.84 *†	89.8
VI	49.4 ± 0.23	35.5 ± 0.92	11.9 ± 1.24	3.2 ± 0.12	NO	68.9 ± 0.51 *†	67.4
VII	66.1 ± 0.17	17.7 ± 0.13	14.1 ± 0.82	2.1 ± 0.85	NO	52.2 ± 0.72 *†	80.6
VIII	61.9 ± 0.11	27.9 ± 0.72	10.2 ± 0.84	NO	NO	48.3 ± 0.92 *†	83.6

^a Comet types defined as T₀, T₁, T₂, T₃, and T₄ (no or very low damage, low, medium, and long DNA migration, and the highest level of DNA damage, respectively); ^b %R, percentage reduction of DNA damage; ^c Values represent mean ± SEM from three independent experiments; n = 5 rats per group; ^d Not observed; ^e Not available; I—Negative control, 1 mL/kg bwt olive oil, i.p.; II—Positive control, 1 mL/kg bwt of CCl₄, 1:1 mixture in olive oil, i.p.; III—1 mg/kg bwt of YY EO + 1 mL/kg bwt of CCl₄, i.p.; IV—200 mg/kg bwt of YY EO + 1 mL/kg bwt of CCl₄, i.p.; V—400 mg/kg bwt of YY EO + 1 mL/kg bwt of CCl₄, i.p.; VI—1 mg/kg bwt of CCP EO + 1 mL/kg bwt of CCl₄, i.p.; VII—200 mg/kg bwt of CCP EO + 1 mL/kg bwt of CCl₄, i.p.; VIII—400 mg/kg bwt of CCP EO + 1 mL/kg bwt of CCl₄, i.p.; * p < 0.05 when compared with the negative control group; ^† p < 0.05 when compared with the positive control group.