Table 2.
Changes in sphingolipid content on RAW 264.7 cells induced by LPS resulting from incubation of L. bicolor honey extract.
| Pathway | Metabolites | LPS Group vs. Blank Group a | Honey Group b vs. LPS Group c | ||||
|---|---|---|---|---|---|---|---|
| p-Value | Log2 (Fold Change) |
Trend | p-Value | Log2 (Fold Change) |
Trend | ||
| Sphingolipid Metabolism/Necroptosis | Ceramide | 0.0087 | 13.36 | up | 0.0007 | −2.38 | down |
| Sphingosine | 0.0040 | 2.26 | up | 0.0380 | −2.22 | down | |
| Sphingosine-1-phosphate (S1P) | 0.0005 | 13.42 | up | 0.0157 | −4.77 | down | |
a Blank group was not treated with L. bicolor honey extract or LPS; b honey group was pretreated with 100 µg/mL of L. bicolor honey extract, then treated with 1 µg/mL of LPS; c LPS group was treated with 1 µg/mL of LPS but not pretreated with L. bicolor honey extract.