Skip to main content
. 2023 Oct 9;13(10):1496. doi: 10.3390/biom13101496

Figure 7.

Figure 7

The AP-induced thigmotaxis behavior was attenuated by GR3027 in the MWM trials. Data are shown as mean area under the curve ± SEM for thigmotaxis path (left picture), length of swim spent close to the wall (% path of max path x days). On the (right picture) is % of time (max. 120 s) spent close to the wall in the Morris water maze for the treatment groups during the five days of testing. Treatments were vehicle (10% Captisol; n = 6), AP (2.2 mg/kg in β-CD; n = 20), T1:0.5 (AP:GR3027; 2.2:1.1 mg/kg in β-CD; n = 7), T1:1 (2.2:2.2 mg/kg in β-CD; n = 20), T1:2.5 (2.2:5.5 mg/kg in β-CD; n = 10), T1:5 (2.2:11 mg/kg in β-CD; n = 15), and GR3027 (11 mg/kg in β-CD; n = 11). Daily i.v. injections were administered 8 min before each rat’s first swim of the day. Letters above bars in left picture indicate statistically significant difference. a = vehicle compared to AP, T1:0.5, T1:1, b = AP compared to T1:2.5, T1:5, GR3027, c = GR3027 compared to AP, T1:0.5, T1:1, and d = T1:5 compared to T1:0.5, T1:1 (see Table 3 for p-values).