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Redox-mediated regulation of I1-FFLPI3K/PTEN. (A) A simplified presentation of the PI3K and PTEN signals invoked downstream to the activation of RTKs. (B) The close-up view of PTEN (AlphaFoldDB: F6KD01) shows the redox-sensitive Cys-71 and Cys-124. (C) Evolutionary conservation of the redox-sensitive Cys-71 and Cys-124 of PTEN (n = 124 species within the subphylum vertebrata). (D). Redox-mediated resolution of the I1-FFLPI3K/PTEN.
