Figure 2.

Non-centrosomal MTOC in epithelial cells adopts a centrosomal MTOC position as epithelial cells transition to mesenchymal cells. There is no well-defined mechanism by which non-centrosomal MTOC is reverted to centrosomal MTOC as epithelial cells convert into mesenchymal cells. The development of centrosomal MTOC from non-centrosomal MTOC as epithelial cell convert into mesenchymal cells is referred as cell polarity reversion. Upon loss of the cell–cell adherent junctions and apical-basolateral cell polarity, the MTOC is gradually developed at the cell center, from which polarized microtubules radiate towards the cell periphery. This is accompanied by gain of adhesive and migratory traits via transitioning cells.