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. 2023 Sep 24;13(10):1438. doi: 10.3390/biom13101438

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© 2023 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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cccDNA downregulation via antihistamines. (A) Dose-dependent effect of Bilastine on nuclear cccDNA in HuH-7 acceptor cells. (B) Relative expression of cccDNA via qPCR in HuH-7 acceptor cells treated with 10 μM antihistamines. *** p < 0.001, ** p < 0.01. (C) Chemical structures of antihistamines and their effect on cccDNA. (D) Effect of antihistamines on 3.5 kb RNAs (pgRNA and pcRNA) in HuH-7 acceptor cells via qPCR. *** p < 0.001, ** p < 0.01. (E) Suppressors of cccDNA levels identified through fluorescence cccDNA-targeted drug screen.