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. 2023 Sep 27;13(10):1461. doi: 10.3390/biom13101461

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© 2023 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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There was no difference between females and males in the amplitude of the response to AMPA in neurons or astrocytes following incubation in decanoic acid nor in the proportion responding. (A) The proportion of neurons responding and the amplitude of response to AMPA in slices incubated in decanoic acid did not differ between the female and male 5xFAD genotype. Further, there was no difference between females and males in the relative fold change in amplitude from control conditions in the 5xFAD neurons when decanoic acid was present (Two-way ANOVA, neurons: p = 0.9793). (B) The response proportion and the amplitude of the response to AMPA in presence of decanoic acid also did not differ in astrocytes between females and males, and there was no difference in the relative fold change in amplitude in presence of decanoic acid when compared to control conditions in the 5xFAD (Two-way ANOVA, Astrocytes: p = 0.3534). ns indicates no significance.