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. 2023 Oct 19;15(20):5043. doi: 10.3390/cancers15205043

Figure 2.

Figure 2

The mechanism of PDT and the synergistic effect of combined ferroptosis. (A) PDT can induce ferroptosis by photochemical reaction and exert a synergistic effect with ferroptosis agonists. (B–D) Nanoparticles coated with photosensitizers and ferroptosis agonists can exert a synergistic effect through enhancing tumor immunology, improving the hypoxia microenvironment and inhibiting tumor angiogenesis. (E) In a hypoxic environment, PDT can act on nucleic acids through a type III photochemical reaction.