Table 1.

Comprehensive Overview of Key Research Studies on Medical Conditions and Their Therapeutic Approaches.

Authors and Year	Study Title	Aim of Study	Main Outcomes	Section
Galleli et al. [170]	A Review of Its Anti-Edematous, Anti-Inflammatory, and Venotonic Properties	Discusses historical and recent pharmacological and clinical data on the anti-edematous, anti-inflammatory, and venotonic properties of escin.	Escin oral dragées and transdermal gel have both demonstrated efficacy in blunt trauma injuries and chronic venous insufficiency.	Edema
Pickkers et al. [200]	Acute Kidney Injury in the Critically Ill: An Updated Review on Pathophysiology and Management	Prediction and early detection of AKI, aspects of pathophysiology, and progress in the recognition of different phenotypes of AKI, as well as an update on nephrotoxicity and organ cross-talk.	Novel developments, including biomarkers and machine learning, hold promise as they are more sensitive to and predictive of the development of AKI.	Renal disease
Thiagarajah et al. [115]	Chloride Channel-Targeted Therapy for Secretory Diarrheas	Analyzes Enterocyte Cl− channels, which represent an attractive class of targets for diarrhea therapy, as they are the final, rate-limiting step in enterotoxin-induced fluid secretion in the intestine.	Antisecretory drug therapy has considerable potential in reducing morbidity and mortality associated with infectious and some drug-induced and other diarrheas.	Diarrhea
Gimbrone et al. [148]	Endothelial Cell Dysfunction and the Pathobiology of Atherosclerosis	Traces the evolution of the concept of endothelial cell dysfunction, focusing on recent insights into the cellular and molecular mechanisms that underlie its pivotal roles in atherosclerotic lesion initiation and progression.	The development of pharmacomimetics of the natural, flow-mediated vasoprotective endothelial phenotype would appear to be a potentially fruitful strategy.	Hypertension