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. 2023 Oct 14;12(20):2452. doi: 10.3390/cells12202452

Table 2.

Similarities Between GIG and POAG.

Elevated IOP due to increased aqueous outflow resistance at TM
Elevated IOP damages unmyelinated axons at ONH
Morphological changes and remodeling of ONH
Progressive loss of RGC axons and soma
Similar pattern of visual field loss
Associated with morphological and molecular changes to the TM

  • Increased deposition of ECM in trabecular beams and JCT

  • Increased TM tissue stiffness

  • Increased ECM synthesis & crosslinking and decreased degradation

  • Reorganization of actin cytoskeleton to form CLANs

  • Decreased TM cellularity

GIG = glucocorticoid-induced glaucoma; POAG = primary open-angle glaucoma; IOP = intraocular pressure; TM = trabecular meshwork; ONH = optic nerve head; RGC = retinal ganglion cell; ECM = extracellular matrix; JCT = juxtacanalicular tissue; CLANs = cross-linked actin networks.