Table 3.

The contribution of CR1 domains to classical pathway C3 Convertase (C4bC2b) DAA.

LHR-A	LHR-B	LHR-C	LHR-D	CP C3 DAA Activity Relative to LHR-ABCD
				60%, 43% a
				12%
				8%, 10% b
				0%
				100%
				100%
				8%
Required	Either site required		Not Required

The filled cells along each row correspond to constructs encoding the relevant LHR domains used experimentally to determine the LHR contribution to DAA, and the right-hand column shows the DAA(s) of that construct relative to LHR-ABCD, based on the available literature [25,61,62]. ^a Percentage DAA relative to LHR-AC. ^b Percentage DAA relative to LHR-A. The bottom row shows the overall LHR domain requirement for DAA that can be inferred from the experimental data. Lectin pathway DAA is assumed to be identical to that of the classical pathway (CP), given the convertases used for both pathways are the same.