Table 4.
The contribution of CR1 domains to classical pathway C5 Convertase (C4bC2bC3b) DAA.
| LHR-A | LHR-B | LHR-C | LHR-D | CP C5 DAA Activity Relative to LHR-ABCD |
|---|---|---|---|---|
| 0.5%, 1% a | ||||
| 3% | ||||
| 95% b | ||||
| 100% | ||||
| Required | Either site required | Not Required | ||
The filled cells along each row correspond to constructs encoding the relevant LHR domains used experimentally to determine the LHR contribution to DAA, and the right-hand column shows the DAA(s) of that construct relative to LHR-ABCD, based on the available literature [25,61,62]. a Percentage DAA relative to LHR-AC. b A separate experiment showed 100-fold greater activity relative to LHR-A. The bottom row shows the overall LHR domain requirement for DAA that can be inferred from the experimental data. Lectin pathway DAA is assumed to be identical to that of the classical pathway.