Figure 1.

Schematic representation of the effect of hyperglycemia on LESCs. Hyperglycemia results in a significant reduction in the expression of putative LESC markers and the number of cells positive for these markers in the limbus, resulting in delayed corneal wound healing (red highlight). Various genetic, biological, pharmacological and surgical interventions have been employed to rescue LESC function and enhance wound healing in organ-cultured diabetic human corneas, cultured diabetic LECs and mouse models of diabetes (green highlight). Upward arrow ($\uparrow$) represents “increasing the amount of”; Downward arrow ($\downarrow$) represents “decreasing the amount of”. Figure generated with BioRender.com.