Figure 1.

Loss of PP1cα moderately decreased agonist-induced integrin α_IIbβ₃ activation. Washed platelets from wild type (WT) and PP1cα^−/− mice under basal (no agonist) or challenged with low-dose agonists such as thrombin (A), ADP (B), and collagen (C) were incubated with anti-JON/A-PE (recognizes active murine α_IIbβ₃) and subjected to flow cytometry. n = 4–5. * p < 0.05.