. 2023 Oct 7;13(10):1424. doi: 10.3390/brainsci13101424

Table 1.

Genetically engineered mouse models used to study optic glioma.

Genotype	Optic Glioma Phenotype	Ref
Nf1^flox/−; hGfap-Cre Nf1^flox/flox; hGfap-Cre	tumor developed by 2 months of age	[35]
Nf1^flox/neo; Gfap-Cre *^#	tumor developed by 3 months of age	[34]
Nf1^flox/neo; Pten^flox/+; Gfap-Cre	tumor developed by 3 months of age	[37]
Nf1^flox/neo; Olig2-Cre	tumor developed by 6 months of age	[109]
Nf1^flox/neo; Prom1-CreER	tumor developed by 3 months of age	[109]
Nf1^flox/R681X; Gfap-Cre	tumor developed by 3 months of age	[39]
Nf1^flox/G848R; Gfap-Cre	no tumor detected by 3 months of age	[39]
Nf1^flox/C383X; Gfap-Cre	25% mice developed tumor by 3 months of age	[36]
Nf1^flox/R1278P; Gfap-Cre	tumor developed by 3 months of age	[36]

* neo, engineered neomycin insertion to disrupt Nf1 function. ^# the activity of the Gfap promoter was detected around E15, whereas the activity of the hGfap promoter was detected around E12.