Table 2.

Critical cell/tissue types and the corresponding molecules in optic glioma pathophysiology.

Cell/Tissue Type	Molecule	Role in Optic Glioma Progression	Ref
Retinal ganglion cells	Midkine	stimulate T cell Ccl4 production by binding to LRP1	[86]
Retinal ganglion cells	HCN	Nf1 mutation induced HCN dysfunction induces neuronal hyperactivity; modulates midkine level	[89]
Optic nerve	ADAM10	increased secretion in response to light-induced neuronal activity; cleaves neuroligin-3	[88]
Optic nerve	Neuroligin-3	required for optic gliomagenesis	[88]
CD8+ T cells	CCL4	stimulate microglial Ccl5 production by binding to CCR5	[86]
Microglia	CCL5	binds to CD44 on tumor cells and increases tumor cell survival	[86]
Microglia	CX3CR1	required for tumorigenesis	[73]