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. 2023 Oct 23;12(20):2509. doi: 10.3390/cells12202509

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© 2023 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Inhibition of SLC38A5 induces changes in ferroptosis-regulating genes. (A) Heat map analysis of the distribution of genes from PANC-1, PANC-GR, and PANC-GR with siSLC38A5 cells. (B) DAVID-based gene ontology bubble plot analysis of mRNA sequencing results from PANC-GR and PANC-GR with siSLC38A5 cells. (C) GSEA for significant enrichment for ferroptosis. (D) Correlation analysis of SLC38A5 and ferroptosis-related genes in pancreatic cancer. (E) mRNA levels of the ferroptosis-related genes were quantified via qPCR in PANC-1, PANC-GR, and PANC-GR with siSLC38A5. All experiments were performed at least three times. Bars represent means ± SD. *, p < 0.05; **, p < 0.01.