Table 4.
Univariate and multivariate analyses of the association between clinical variables and early BCR in high-risk PCa patients after CIRT and ADT.
| Variables | Univariate | p Value | Multivariate | p Value | ||
|---|---|---|---|---|---|---|
| Early BCR (%) | Non-Early BCR (%) | HR | 95%CI | |||
| Age ≥ 70 vs. < 70 (years) | 4.9 | 5.7 | 0.77 | |||
| PSA ≥ 50 vs. < 50 (ng/mL) | 12.5 | 4.7 | 0.02 | - | 0.29 | |
| cT3b vs. cT3a-cT1 | 16.4 | 4.3 | <0.01 | 3.63 | 1.76–7.49 | <0.01 |
| GS ≥ 9 and 3 + 5 vs. GS ≤ 4 + 4 | 6.9 | 4.0 | 0.07 | - | 0.41 | |
| %PC ≥ 75% vs. < 75% | 14.6 | 3.7 | <0.01 | 3.51 | 1.84–6.69 | <0.01 |
ADT: androgen deprivation therapy, BCR: biochemical recurrence, IQR: interquartile range, %PC: percentage of positive biopsy cores, PSA: prostate-specific antigen, SD: standard deviation, STAMPEDE: Systemic Therapy in Advancing or Metastatic Prostate cancer.