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Effect of NaHCO3 on PD-L1 expression in vivo. Mice were treated with 200 mmol/L sodium bicarbonate solution or regular tap water (control) by free oral ingestion from Day 3 to Day 23. Flow cytometry dot plots (A) and mean fluorescence (B) of tumor tissue PD-L1 expression (* p < 0.05 for NaHCO3 vs. control). (C) Tumor tissue PD-L1 mRNA analyzed by qPCR (* p < 0.05 for NaHCO3 vs. control).
