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. 2023 Oct 19;15(20):5054. doi: 10.3390/cancers15205054

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© 2023 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Differential effects of aspirin and naproxen intervention on angiogenesis and apoptosis markers in the prostate of TMPRSS2-ERG fusion-driven and non-fusion-driven Hi-Myc PCa models. NSAID effects on (A) CD-31 (PECAM-1) angiogenesis marker, and (B) cleaved-caspase-3 (apoptosis marker) in dorsolateral prostate of TMPRSS2-ERG. Pten^flox/flox (+TAM) (left-panel), and Hi-Myc^+/− (right-panel) mice. Representative pictographs (×400 magnification) of DAB-stained prostate tissues showing brown-colored positive staining (CD-31: endothelial membrane junction, c-caspase-3: cytoplasmic/nuclear) are shown above each panel. Scale bar represents 20 µm. Doses used were aspirin 700 ppm (A700); aspirin 1400 ppm (A1400); naproxen 200 ppm (N200); naproxen 400 ppm (N400). Age-matched NSAID untreated mice [(No-TAM) and FVB (WT)] represent respective controls for each strain. Quantified data are represented as Columns (mean for each group): [TMPRSS2-ERG. Pten^flox/flox (+TAM) and Hi-Myc^+/− (untreated and NSAID-fed) n =10 tissues/group; No-TAM: n = 4 tissues; FVB (WT): n = 3 tissues; bars represent SEM. *, p ≤ 0.001; #, p ≤ 0.01; $, p ≤ 0.05; ns, p > 0.05.