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Schematic diagram on the effect of L-CM treatment on osteoblast differentiation and bone formation. Our results present a clear reduction in osteoblast proliferation, differentiation, function, and gene expression when treated with L-CM (B) in comparison to the untreated control (A). L-CM was also found to inhibit bone formation (B) when compared to the untreated control (A) in an ex vivo model for bone formation.
