Table 1.

Multivariable General Estimating Equation Models Predicting tenofovir, lamivudine, and efavirenz cervicovaginal fluid concentrations with Community State Types.

Community State Type*	Estimate	Standard Error	P-value
Tenofovir
I	REF	REF	REF
III-A	−0.21	0.12	0.078
III-B	−0.34	0.15	0.026*
IV-A	−0.18	0.13	0.15
IV-B	−0.18	0.14	0.19
IV-C	0.0287	0.13	0.83
Lamivudine
I	REF	REF	REF
III-A	−0.25	0.09	0.010*
III-B	−0.33	0.17	0.052
IV-A	−0.29	0.12	0.019*
IV-B	−0.28	0.11	0.016*
IV-C	−0.11	0.11	0.34
Efavirenz
I	REF	REF	REF
III-A	−0.25	0.15	0.10
III-B	−0.050	0.16	0.75
IV-A	−0.23	0.14	0.10
IV-B	−0.27	0.17	0.11
IV-C	−0.42	0.16	0.0094*

^*Community state types describe the different vaginal bacterial communities present in the participants of the current study. They were defined using Bray-Curtis dissimilarity measure and Ward linkage hierarchical clustering. CST I and III are dominated by L. crispatus and L. iners respectively, whereas CST IVs comprise of diverse sets of anaerobic bacteria and low to no lactobacilli.