Skip to main content
. 2023 Oct 13;15(20):4978. doi: 10.3390/cancers15204978

Figure 2.

Figure 2

CNV profiles and IHC staining patterns of p16 and MTAP in a case with WT ((A), P27), a case with homozygous CDKN2A-MTAP deletion ((B), P75), and a case with heterozygous CDKN2A-MTAP deletion ((C), P5), respectively. While the case with homozygous loss (B) shows consistent loss of MTAP staining, MTAP immunoreactivity is retained in some cases with heterozygous loss, as shown here in (C). Note the positive internal control for p16 and MTAP of stromal cells between the negative tumor cell infiltrates as marked by blue arrows in (B). CNV results are shown with a zoom-in into chromosome 9, which harbors the CDKN2A and MTAP loci on q21.3. H&E, p16, and MTAP staining are shown in 20× magnification. (Figure S1 provides additional information).