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. 2023 Oct 13;15(20):4978. doi: 10.3390/cancers15204978

Figure 3.

Figure 3

Heterogeneity of p16 and MTAP protein expression in PM observed in 17% of cases. (A) shows an example of a tumor sample with wild-type CDKN2A/MTAP and retained protein expression with very high spatial heterogeneity, and p16 and MTAP negativity in up to 50% of tumor cells (tumor area left of red line). The wild-type case presented in (B), however, showed the expected 100% p16 and MTAP positivity in one area of the obtained section (red circle, middle row), combined with only focal loss of both p16 and MTAP in around 10% of the tumor cells in a different area (black circle, bottom row). Staining positive tumor cells are marked with red arrow, while staining negative tumor cells are marked with black arrows. (Magnification: 20×).