Table 2.
Dermatokinetic parameters of STCN–CF gel and STCN–TL gel.
Dermatokinetics Parameters |
STCN–CF Gel | STCN–TL Gel | ||
---|---|---|---|---|
Epidermis | Dermis | Epidermis | Dermis | |
Tskin max (h) | 1.5 ± 0.2 | 2 ± 0.2 | 1.5 ± 0.3 | 2 ± 0.2 |
Cskin max (µg/cm2) | 85.15 ± 8.64 | 74.66 ± 5.21 | 198.11 ± 3.42 | 166.75 ± 6.42 |
AUC0-8 (µg/cm2 h) | 410.49 ± 12.52 | 307.67 ± 17.65 | 937.70 ± 27.33 | 795.01 ± 21.43 |
Elimination rate constant [Ke (h−1)] | 0.111 ± 0.052 | 0.132 ± 0.081 | 0.117 ± 0.041 | 0.059 ± 0.023 |