Figure 9.
(A) Caveolin-1 expression. Caveolin-1 expression was highly significantly decreased in DD-FBs compared with CTS-FBs (w/o) (n = 14). (B) Analysis of α-SMA expression after a 5-FU treatment (80 µg/mL). α-SMA expression was significantly inhibited if MD- and CTS-FBs were treated with TGF-β1 and 5-FU compared to TGF-β1 alone. Furthermore, α-SMA expression was significantly inhibited in DD-FBs compared with CTS-FBs (w/o) if treated with TGF-β1 and 5-FU (n = 7). (C) Visualization of caveolin-1 expression in MD- and CTS-FBs. It could be observed that caveolin-1 expression increased if FBs were treated with 5-FU. * p ≤ 0.05; ** p ≤ 0.01; **** p ≤ 0.0005. Bars represent the mean ± SD of individual experiments indicated.