Table 1.

Summary of possible examinations and necessary reagents on the ROTEM^® delta device [9].

Assay	Investigated Area	Used Reagent
INTEM	Intrinsic coagulation pathway FXII, FXI, FIX, FVIII, FX, FV, FII, FI, fibrin, platelets, fibrinolysis	partial thromboplastin, ellagic acid
EXTEM	Extrinsic coagulation pathway FVII, FX, FV, FII, FI, fibrin, platelets, fibrinolysis	recombinant tissue factor, phospholipids
FIBTEM	Contribution of fibrinogen to the clot formation after platelet inactivation	recalcification and platelet inhibitor cytochalasin D
APTEM	Inhibition of fibrinolysis, comparison to EXTEM can indicate/detect hyperfibrinolysis	recalcification and fibrinolysis inhibitor aprotinin/tranexamic acid
HEPTEM	Heparin inactivation in heparinized patients	recalcification, heparinase I *

Legend: F—factor. * heparinase I (neutralase I) is an enzyme that specifically degrades heparin by catalyzing the cleavage of the saccharide bonds found in the heparin molecule.