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mTORC1 and mTORC2 complexes and downstream cellular functions. mTORC1 is composed of a core complex of mTOR, Raptor, and mLST8, which is inhibited by DEPTOR and PRAS40. mTORC2 comprises a core of mTOR, Rictor, and mLST8 that is inhibited by DEPTOR and regulated by Protor1/2 and mSin1. mTORC1 versus mTORC2 activation affects diverse cellular functions.
