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Potential regulation pathways of cranial neural crest cells production. miRNAs can influence Slit/Robo binding and functions. Slit/Robo can impact the expression pattern of the dorso-ventral neural tube genes. Heparan sulfate moduiates the Slit/Robo interactions and SHH can establish a ventro-dorsal gradient in the neural tube to regulate the PAX/HNK1 family gene expression.
