Table 5.

Comparison of patients with potentially needed and performed genetic testing between the inflammatory and the non-inflammatory groups shown for age categories. Percentages of patients with potential need and performed genetic testing refer to the total cohort, whereas percentages of inflammatory and non-inflammatory groups refer to the number of patients with potential need or performed genetic testing, respectively. Differences between groups (excluding age groups ‘10 $\ge$ age < 20’ and ‘90 $\ge$ age < 100’) are tested using the chi-square test, with significance indicated by p < 0.05. After Bonferroni adjustment for multiple testing, results are shown with a local significance value of 0.003.

	Total Cohort [n (%)]	$\ge$10 yrs <20 yrs [n (%)]	$\ge$$20 \mathbf{y}\mathbf{r}\mathbf{s}$ <30 yrs [n (%)]	$\ge$$30 \mathbf{y}\mathbf{r}\mathbf{s}$ <40 yrs [n (%)]	$\ge$40 yrs <50 yrs [n (%)]	$\ge$$50 \mathbf{y}\mathbf{r}\mathbf{s}$ <60 yrs [n (%)]	$\ge$60 yrs <70 yrs [n (%)]	$\ge$70 yrs <80 yrs [n (%)]	$\ge$80 yrs <90 yrs [n (%)]	$\ge$90 yrs [n (%)]	p
Patients’ numbers, total	2490 (100)	7	186	219	342	627	522	378	195	14
Patients with potential need for genetic testing	1428 (57.3)	4 (57.1)	96 (51.6)	116 (53.0)	186 (54.4)	349 (55.7)	327 (62.6)	223 (59.0)	115 (59.0)	12 (85.7)
-inflammatory group	1204 (77.1)	4 (100)	76 (79.2)	95 (81.9)	154 (82.8)	302 (86.5)	275 (84.1)	187 (83.9)	102 (88.7)	9 (75.0)	*
-non-inflammatory group	224 (24.1)	0 (0)	20 (20.8)	21 (18.1)	31 (16.7)	47 (13.5)	52 (15.9)	36 (16.1)	13 11.3)	3 (25.0)	*
Patients with performed genetic testing	1332 (53.5)	4 (57.1)	122 (65.6)	143 (65.3)	217 (63.5)	371 (59.2)	270 (51.7)	150 (39.7)	53 (27.2)	2 (14.3)	*
-inflammatory group	926 (59.3)	3 (75.0)	88 (72.1)	97 (67.8)	141 (65.0)	250 (67.4)	193 (71.5)	110 (73.3)	42 (79.2)	2 (100)	*
-non-inflammatory group	406 (43.7)	1 (25.0)	34 (27.9)	46 (32.2)	76 (35.0)	121 (32.6)	77 (28.5)	40 (26.7)	11 (20.8)	0 (0)	*
Patients with performed out of potentially needed genetic testing	93.2%	100%	127.1%	123.3%	116.7%	106.3%	82.6%	67.3%	46.1%	16.7%	*
- inflammatory group	76.9%	75%	115.8%	102.1%	91.6%	82.8%	70.2%	58.8%	41.2%	22.2%	*
- non-inflammatory group	181.3%	-	170.0%	219.0%	245.2%	257.4%	148.1%	111.1%	84.6%	-	*

*, p < 0.001