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The main regulatory mechanisms of ferroptosis. These mechanisms include the inhibition of the cystine/glutamate antiporter system (system xc−), leading to depletion of intracellular glutathione and the accumulation of lipid peroxidation products due to the oxidation of polyunsaturated fatty acids (PUFAs) by reactive oxygen species (ROS) and the dysregulation of iron metabolism through transferrin receptor 1 (Tf1).
