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. 2023 Oct 14;24(20):15179. doi: 10.3390/ijms242015179

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© 2023 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Activation of TUSC3 enhances TMZ sensitivity in both MGMT-M and MGMT-UM GSCs. (A) Immunoblotting and qPCR validation of TUSC3 overexpression in GSCs. (B) TMZ IC-50 alteration in wild-type control and TUSC3-overexpressed GSCs. (C) Knockout efficiency of TUSC3 examined by immunoblotting in MGMT-M and MGMT-UM GSCs. (D) TMZ IC-50 alteration in TUSC3 rescue experiment (transient TUSC3 overexpression). EV, empty vector; WT, wild-type control; TUSC3-KO, TUSC3 knockout GSCs. Data are presented as mean ± SD. n = 3; *, p < 0.05.