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. 2022 Oct 19;11(4):2133877. doi: 10.1080/21688370.2022.2133877

Figure 3.

Figure 3.

Epithelial barrier damaging factor cause series of pathological events. The external barrier damaging stimuli impair the epithelial barrier, increasing its permeability and facilitating the entry of foreign substances and microbial translocation to interepithelial and subepithelial regions. A cascade of events follows including continuous immune responses against allergens and the development of tissue microinflammation, which have been implicated in the development of various diseases due to a vicious cycle of a leaky barrier and chronic inflammation.