Table 2.

List of differently expressed genes of top-ten enriched KEGG pathways.

KEGG Pathway	Differentially Expressed Genes	p-Value	False Discovery Rate	Bonferroni
Metabolic pathways	cyp7a1, si:ch73-111m19.2, LOC559107, tdo2a, gda, cyp2r1, gls2a, pde6c, bco1l, cyp27b1, elovl4b, cyp8b1, nme2a, agxta, chia.2, zgc:77938, pde6b, ATP8, gyg1b, si:ch211-135f11.4, arg1, gc3, cyp2p9, alas2, gucy2f, tecra, si:ch211-217a12.1, sdsl, zgc:103586, hsd20b2, pnp4b, hacd1, agxtb, pde6g, zgc:153896, rdh8b, ND3, si:ch211-264e16.1, cyp2p8, si:dkey-91i10.3, si:ch211-214p16.3, spam1, ND4L, tecrl2b, nt5e, si:ch211-132f19.7, cyp2p6, anpepb, dpm3, ugt5d1, ugt1b5, LOC100331665, zgc:92162, zgc:153704, si, gpx8, ATP6, nt5c1aa, pde6a, chs1, ND1, dgat2, cyp2p7, hyal6, si:ch211-127i16.2, ugt5b3, hao2, si:dkey-73n8.3, mdh1ab, aanat1, g6pca.2, acer1, cyp27a1.4, ND2, cel.2, pfkma, atpv0e2, entpd8, fam213b, cel.1, csgalnact1b, dgat1a, cahz, ugt1b2, agpat3, haao, lpin1, pcxb, gls2b, elovl8a, gpat3, hsd11b1la, sephs1, guk1b, pisd, ptgdsb.2, sgms2, etnppl, dhrs3a, ndufa4, si:dkey-78a14.4, acot12, upp1, tecrl2a, ND5, ahcyl1, LOC101886891, COX3, ugt5g1, ckmt2a, ND4, ND6, gbgt1l2, gstt2, ugt5b4, tdh2, ca2, adss, cyp27a1.2, suv39h1a, LOC100536156, si:ch73-55i23.1, si:ch211-197l9.4, si:ch73-71d17.1, dpys, ptges3a, got2a, zgc:153031, b3gnt5a, mocs1, ndufa11, pde5aa, entpd5a, elovl2, amd1, fech, atp5g3a, st3gal7, pnp6, th2, gstk1, entpd3, ugt1a4, gal3st1a, cds1, pdha1b, alg10, ndufab1b, mcee, hpda, nme6, gucy1a3, CYTB, si:ch211-256m1.8, ca12, alpl, si:dkey-103j14.5, gc2, pcyt1bb, pde6d, uqcr10, mars, atic, cbsb, LOC100333801, adprm, cbr1l, eno4, sat1a.2, nnt2, ak7b, ckmb, gnsb, pnp5b, LOC103911725, Glyctk, tcirg1b, shmt2, lss, galm, ugt2a6, paics, gnpda2, ptgis, renbp, si:ch211-276a23.5, got1l1, gsr, phgdh, ckma, gsto2, pla2g4aa, hk2, hyi, zgc:163121, ugt2a4, acsl4b, abat, hao1, taldo1, sqrdl, cyp51, galns, gfpt1, acsl2, odc1, amdhd2, adi1, scd, gpx1b, gpx3, psat1, eprs, si:dkey-175m17.6, ethe1, mthfr, pycr1b, p4ha2, pfkfb3, tph1b, adh8a, tdo2b, cmbl, bhmt, rdh12l, ptgs2b, mthfd1l, gstp1, si:ch211-199m3.4, dao.1, hmox1a, sqlea, ptgs2a, gldc, cox4i1l, p4ha1b, cyp24a1, gstp2	1.47446 × 10−90	2.24117 × 10−88	2.24117 × 10−88
Phototransduction	opn1mw1, gngt1, rho, rhol, guca1c, guca1d, grk1b, gnat2, grk7a, guca1e, opn1mw2, guca1g, pde6b, gc3, guca1b, gucy2f, rcvrn3, cnga1, si:dkey-22i16.2, rgs9a, slc24a1, pde6g, pde6a, grk1a, calm3a, saga, calm1b, rcvrna, rcvrn2, gc2	4.87074 × 10−27	7.40352 × 10−25	3.70176 × 10−25
Aminoacyl-tRNA biosynthesis	trnH, trnD, trnS2, trnK, trnL2, trnE, trnN, trnY, trnG, trnI, trnQ, trnP, trnM, trnR, trnC, trnT, trnL1, trnF, farsa, mars, dars, gars, nars, vars, yars, aars, iars, eprs, tars	7.95807 × 10−22	1.20963 × 10−19	4.03209 × 10−20
MAPK signaling	hsc70, ppm1na, fgf1a, tgfa, cacng6b, ppm1nb, fgf4, dusp10, nr4a1, dusp2, si:ch73-55i23.1, mapkapk2b, ppp3r1a, cacna1sb, egf, fgf1b, cacng8b, LOC795766, fgf20a, tgfbr1b, fosab, csf1ra, flna, insrb, met, taok3a, fgfr1b, gadd45bb, map3k14a, tnfrsf1a, irak4, kitlgb, pla2g4aa, tab1, gadd45aa, prkacba, nfkb1, angpt2a, mapk12b, gadd45ba, epha2a, rasgrp3, jun, ddit3, pgfa, gadd45ga, si:dkey-4p15.3, fas, mknk2b, hspb1, il1b, hsp70.3, hsp70.1, hsp70l	3.48302 × 10−19	5.29419 × 10−17	1.32355 × 10−17
Neuroactive ligand-receptor interaction	gabra6a, drd4b, sstr2b, si:dkey-1h24.2, gabrr1, LOC100007535, try, mc1r, lpar4, mtnr1ab, prlra, glrba, ednrba, si:dkey-202l22.3, adrb2b, chrna3, lpar6b, gabra6b, edn3b, prlhr2a, ptger1a, adra1bb, LOC100332187, gabrz, LOC556532, apln, p2ry1, chrna2b, htr1ab, adra1d, LOC100330650, Chrne, agtr2, vipr2, oxtrl, glra3, galn, ltb4r2a, npb, tbxa2r, p2ry6, LOC567978, Agt, htr1fb, lepa, c5, lepr, chrna5, c3a.3, chrng, sst1.2, f2r, pomca, ptger2b, f2rl1.2, ltb4r2b, rln1, c3a.6, c3a.1, adma	9.66551 × 10−17	1.46916 × 10−14	2.93831 × 10−15
Necroptosis	usp21, slc25a6, slc25a4, si:dkeyp-50d11.2, tlr4ba, camk2d1, si:ch73-55i23.1, h2afx, stat1a, tnfrsf1a, jak1, casp8, caspa, pla2g4aa, tnfaip3, irf9, LOC100006428, zgc:194125, zgc:92066, zgc:92480, si:ch211-202f3.3, hsp90aa1.1, zgc:198419, zgc:109934, stat3, zgc:173593, zgc:173594, fas, LOC558816, stat1b, sqstm1, il1b, hsp90aa1.2	1.80786 × 10−14	2.74794 × 10−12	4.5799 × 10−13
Adregenic signaling in cardiomycetes	atp1b2b, cacng6b, si:ch211-132f19.7, scn4bb, zgc:163073, atp1a3b, adrb2b, calm3a, pln, scn4ba, slc9a1, myl2b, si:ch211-225p5.8, atp1b2a, adra1bb, camk2d1, calm1b, adra1d, cacna1sb, cacng8b, agtr2, tnnt2d, creb5a, creb3l3a, cmlc1, cremb, creb3l3l, atp1a1a.2, agt, acta1a, prkacba, tpma, mapk12b, actc1b, tnnt2c, pik3r5,	2.96038 × 10−14	4.49978 × 10−12	6.42826 × 10−13
Purine metabolism	Gda, pde6c, nme2a, pde6b, gc3, gucy2f, pnp4b, pde6g, nt5e, si:ch211-132f19.7, nt5c1aa, pde6a, entpd8, guk1b, adss, LOC100536156, pde5aa, entpd5a, pnp6, entpd3, nme6, gucy1a3, gc2, pde6d, atic, adprm, ak7b, pnp5b, paics, si:ch211-199m3.4	7.85124 × 10−14	1.19339 × 10−11	1.49174 × 10−12
Calcium signaling pathway	camk1ga, si:rp71-17i16.4, phkg1a, mylk4b, stim2a, mylk4a, si:dkey-1h24.2, fgf1a, camk1gb, mylk2, si:ch211-132f19.7, slc25a6, fgf4, phkg1b, slc25a4, ednrba, adrb2b, calm3a, pln, ptger1a, adra1bb, LOC101886891, camk2d1, camk4, calm1b, ppp3r1a, adra1d, cacna1sb, egf, fgf1b, fgf20a, oxtrl, ltb4r2a, met, fgfr1b, mst1ra, mst1, tbxa2r, prkacba, mcoln3a, f2r, ltb4r2b, cxcr4a	1.84649 × 10−13	2.80666 × 10−11	2.98174 × 10−12
Vascular smooth muscle contraction	mylk4b, mylk4a, mylk2, si:ch211-132f19.7, zgc:92162, LOC101885790, calm3a, ppp1r14aa, edn3b, adra1bb, acta2, calm1b, si:ch73-55i23.1, prkg1b, adra1d, cald1b, cacna1sb, myh11a, gucy1a3, ramp2, nppa, prkg1a, LOC567978, agt, pla2g4aa, prkacba, myh9a, arhgef1b, si:ch73-265d7.2, adma	1.96167 × 10−13	2.98174 ×0−11	2.98174 × 10−12

Upregulated genes (≥2 fold) are shown in bold text.