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. 2023 Oct 17;24(20):15271. doi: 10.3390/ijms242015271

Figure 6.

Figure 6

EGF increased the expression of GnRHR and GnRH-II in decidual stromal cells. Human decidual endometrial stromal cells were treated with 100 ng/mL of EGF for 24 h and then seeded using real-time PCR and immunoblot analysis. EGF-treated cells reveal increased mRNA expression of GnRH-I receptors (A) and GnRH-II (B) compared with untreated controls. (C) EGF-treated cells reveal increased protein expression of GnRH-I receptors compared with untreated controls. (D) Knockdown of endogenous EGFR with treatment with 50 nM EGFR siRNA significantly suppressed the EGF-induced mRNA expression of GnRH-I receptors and GnRH-II (E).