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. 2023 Oct 18;24(20):15315. doi: 10.3390/ijms242015315

Figure 6.

Figure 6

VD inhibits ferroptosis through the Nrf2/HO-1 pathway. The HT22 cells were treated with D-gal (250 mM) and VD (200 nM) for 24 h. Prior to this treatment, the HT22 cells were pretreated with ML385 for 1 h. (A–F) Protein expression of Nrf2, HO-1, ACSL4, ALOX15 (n = 5), GPX4 (n = 7). Image J software was used to quantify Nrf2, HO-1, ACSL4, ALOX15, and GPX4 relative density values relative to β-actin. Compared with the control group, * p < 0.05, ** p < 0.01; compared with the D-gal group, # p < 0.05, ## p < 0.01; compared with the D-gal + VD group, & p < 0.05.