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Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
The anti-aging mechanism of VD in aging hippocampal neurons. VD binds to its receptor, the VDR, which inhibits ferroptosis by upregulating the Nrf2/HO-1 pathway, reduces hippocampal neuronal damage, and improves learning and memory in aging mice.