Table 1.

Key nodes information in the PPI network.

No.	Name	Uniprot ID	Degree	Betweenness Centrality	Closeness Centrality
1	INS	P01308	95	0.120473547	0.694690265
2	AKT1	P31749	94	0.108167587	0.707207207
3	CASP3	P42574	74	0.024572104	0.633064516
4	EGFR	P00533	72	0.029317310	0.620553360
5	STAT3	P40763	63	0.021227013	0.601532567
6	APP	P05067	62	0.035526890	0.608527132
7	MTOR	P42345	58	0.018850365	0.596958175
8	MMP9	P14780	58	0.013916864	0.579335793
9	ESR1	P03372	57	0.020596430	0.594696970
10	PPARG	P37231	57	0.020462185	0.581481481
11	MAPK1	P28482	57	0.022965376	0.592452830
12	NGF	P01138	57	0.018801898	0.594696970
13	TLR4	O00206	53	0.016064887	0.566787004
14	PTGS2	P35354	52	0.007247996	0.570909091
15	ERBB2	P04626	50	0.010049860	0.564748201
16	LEP	P41159	50	0.014671748	0.572992701
17	CAV1	Q03135	49	0.012189853	0.568840580