Table 4.
Impact of CPAP therapy on asthma severity and control.
| Author | Year | Sample | Study Design | Findings |
|---|---|---|---|---|
| Lafond [69] | 2007 | n = 20 OSA and asthma | Prospective, 6 weeks after CPAP therapy | CPAP use 6.7 h/d ↔ airway responsiveness, %FEV1, FEV1/FVC ratio ↑ asthma-specific quality of life |
| Teodorescu [16] | 2012 | n = 75 CPAP therapy, OSA and asthma | Cross-sectional | ↓ persistent daytime asthma symptoms ↔ persistent nighttime asthma symptoms |
| Shaarawy [73] | 2013 | n = 15 uncontrolled asthma and OSA | Prospective, 6 weeks after CPAP therapy | ↓ Epworth sleepiness scale ↓ arousal index ↔ % FEV1, %FVC, FEV1/FVC ratio ↔ ACT score |
| Kauppi [68] | 2016 | n = 152 CPAP started after asthma treatment | Cross-sectional, survey questionnaire | CPAP use 6.3 h/d, mean 5.7 years. ↓ self-reported asthma severity and ↑ACT score without significant changes in BMI ↓ daily rescue medication use |
| Serrano-Pariente [71] | 2017 | n = 99 OSA and asthma | Prospective, before and after 6 months of CPAP | ↓ asthma control questionnaire score ↓ % of uncontrolled asthma ↓ % of asthma attacks ↓ GERD symptoms ↓ positive bronchodilation test ↓ FeNO ↑ Asthma control and ↑ quality of life among patients compliant with CPAP (≥4 h/night) vs. noncompliant subjects. |
| Shaker [74] | 2017 | n = 12 OSA and asthma | Prospective, 3 months after CPAP therapy | ↓ daytime and nighttime asthma symptoms ↓ GERD symptoms ↓ difficult to control asthma ↓ Epworth sleepiness scale ↑ %FEV1 ↑ FEV1/FVC ratio ↑ sleep efficiency ↓ total sleep time |
| Ng [72] | 2018 |
n = 17 CPAP group n = 20 control group Nocturnal asthma symptoms and OSA |
Randomized controlled trial | CPAP use, 5.0 h/d at 1 month and 5.2 h/d at 3 months ↓ Epworth sleepiness score ↑ asthma specific quality of life ↑ vital domain of quality of life ↔ ACT score ↔ asthma exacerbation rate, spirometry, and airway responsiveness |
| Cisneros [70] | 2023 | n = 100 OSA and asthma | Retrospective, before and ≥3 months after CPAP | ↑ clinical asthma control ↑ ACT score |
ACT, asthma control test; CPAP, continuous positive airway pressure; FeNO, fractional exhaled nitric oxide; FEV1, forced expiratory volume in 1 s; FVC, forced vital capacity; GERD, gastroesophageal reflux disease; OSA, obstructive sleep apnea; PSG, polysomnography; : increased, : decreased, ↔: unchanged.