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Hexestrol in vivo activity. Mice were infected with 10 PFU of N09 and treated or not with hexestrol (60 µg/mouse). (A) Mouse survival curves. (B) Daily weight monitoring of infected mice. (C) AUC calculation of weight curve. AUC was calculated for each individual weight curve during the 5 first days of infection. An asterisk (*) indicates a significant difference (p < 0.05) obtained by the Mann–Whitney test.
