Table 1.

Potential consequences arising from a delayed diagnosis or a misdiagnosis.

CONSEQUENCES OF DELAYED DIAGNOSIS OR MISDIAGNOSIS: SUMMARY KEY POINTS
Progression of cardiac involvement with more severe disease at diagnosis potentially reduces the efficacy of TTR stabilizing therapies [196,197].
Use of inappropriate treatment or diagnostic tests (invasive and/or non-invasive) for the misdiagnosed conditions [36,196]. – discomfort and unnecessary risks for patients – increased economic burden
Evaluation by multiple healthcare providers before ATTR-CM diagnosis – anxiety and distrust
Recurrent hospitalizations due to heart failure (common) – poor quality of life [26]
Delay in beginning a specific treatment for ATTR-CM, with the potential to change favorably the natural history and the prognosis.